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Research has established that gingivitis without
periodontitis is the condition that is evident at a lower range of GCF
production but when the GCF is above this threshold, this signals a level of
bacterial activity that heralds arrival of periodontitis (Lee et al., Alpha
1-Proteinase inhibitor in gingival crevicular fluid of humans with adult
periodontitis: serpinolytic inhibition by doxycycline. Journal of
Periodontal Research 32: 9, 1997). At that point, collagenase, a key
degradative protease appears in the GCF and rises within the crevice or
pocket to levels where destruction of epithelial attachment and other
periodontal structures readily occurs. |
